基因名：
MSH3
产品别名：
DUP； FAP4； MRP1； MSH3； mutS homolog 3； mutS homolog 3； DNA mismatch repair protein Msh3； divergent upstream protein； epididymis secretory sperm binding protein； hMSH3； mismatch repair protein 1； 错配修复蛋白3；
背景信息：
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
