基因名：
MYC
产品别名：
MRTL； MYCC； bHLHe39； c-Myc； MYC； MYC proto-oncogene, bHLH transcription factor； MYC proto-oncogene, bHLH transcription factor； myc proto-oncogene protein； avian myelocytomatosis viral oncogene homolog； class E basic helix-loop-helix protein 39； myc-related translation/localization regulatory factor； proto-oncogene c-Myc； transcription factor p64； v-myc avian myelocytomatosis viral oncogene homolog； v-myc myelocytomatosis viral oncogene homolog； myc蛋白； V-Myc骨髓细胞瘤病毒癌基因同源物(MYC)； 磷酸化致癌基因C-Myc； 致癌基因C-Myc；
背景信息：
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].
