基因名：
NDUFS1
产品别名：
CI-75Kd； CI-75k； MC1DN5； PRO1304； NDUFS1； NADH:ubiquinone oxidoreductase core subunit S1； NADH:ubiquinone oxidoreductase core subunit S1； NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial； NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)； complex I 75kDa subunit； complex I, mitochondrial respiratory chain, 75-kD subunit； mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit； 泛醌NADH脱氢酶Fe-S蛋白1(NDUFS1)； 线粒体复合物NDUFS1蛋白；
背景信息：
Ndufs1 belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. Ndufs1 has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in Ndufs1 gene are associated with complex I deficiency.
