基因名：
NEDD8
产品别名：
NEDD-8； NEDD8； NEDD8 ubiquitin like modifier； NEDD8 ubiquitin like modifier； NEDD8； neddylin； neural precursor cell expressed, developmentally down-regulated 8； ubiquitin-like protein Nedd8； 泛素样蛋白NEDD8；
背景信息：
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.
