基因名：
NFKB1
产品别名：
CVID12； EBP-1； KBF1； NF-kB； NF-kB1； NF-kappa-B1； NF-kappaB； NF-kappabeta； NFKB-p105； NFKB-p50； NFkappaB； NFKB1； nuclear factor kappa B subunit 1； nuclear factor kappa B subunit 1； nuclear factor NF-kappa-B p105 subunit； DNA-binding factor KBF1； nuclear factor NF-kappa-B p50 subunit； nuclear factor kappa-B DNA binding subunit； nuclear factor of kappa light polypeptide gene enhancer in B-cells 1； 核因子κB(NFkB)； 磷酸化细胞核因子p50/k基因结合核因子； 细胞核因子p105/k基因结合核因子； 细胞核因子p50/k基因结合核因子；
背景信息：
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
