基因名：
NFKB2
产品别名：
CVID10； H2TF1； LYT-10； LYT10； NF-kB2； p100； p49/p100； p52； NFKB2； nuclear factor kappa B subunit 2； nuclear factor kappa B subunit 2； nuclear factor NF-kappa-B p100 subunit； DNA-binding factor KBF2； NFKB, p52/p100 subunit； lymphocyte translocation chromosome 10 protein； nuclear factor Kappa-B, subunit 2； nuclear factor NF-kappa-B p52 subunit； nuclear factor of Kappa light chain gene enhancer in B cells 2； nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)； oncogene Lyt-10； transcription factor NFKB2； 核因子κB2(NFkB2)； 磷酸化细胞核因子/k基因结合核因子p100； 磷酸化细胞核因子p100基因结合核因子； 细胞核因子/k基因结合核因子 p52/p100；
背景信息：
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
