基因名：
NFKBIE
产品别名：
IKBE； NFKBIE； NFKB inhibitor epsilon； NFKB inhibitor epsilon； NF-kappa-B inhibitor epsilon； I-kappa-B-epsilon； NF-kappa-BIE； ikB-E； ikB-epsilon； ikappaBepsilon； nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon； KB抑制蛋白激酶ε； NF-kappa-B抑制子epsilon； 磷酸化KB抑制蛋白激酶ε；
背景信息：
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.
