基因名:
NMT1
产品别名:
HsNMT1; NMT; NMT1; N-myristoyltransferase 1; N-myristoyltransferase 1; glycylpeptide N-tetradecanoyltransferase 1; alternative, short form NMT-S; long form, NMT-L; myristoyl-CoA:protein N-myristoyltransferase 1; protein-lysine myristoyltransferase NMT1; type I N-myristoyltransferase; 豆蔻酰基转移酶1;
背景信息:
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311)