基因名：
NOTCH1
产品别名：
AOS5； AOVD1； TAN1； hN1； NOTCH1； notch receptor 1； notch receptor 1； neurogenic locus notch homolog protein 1； Notch homolog 1, translocation-associated； notch 1； translocation-associated notch protein TAN-1； Notch 1蛋白； Notch1蛋白； 易位关联Notch同源物1(TAN1)； 活化的Notch1蛋白； 跨膜受体蛋白Notch-1；
背景信息：
Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain and a PEST sequence. Notch1 may play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation and may be involved in mesoderm development, somite formation and neurogenesis.
