基因名：
NOTCH3
产品别名：
CADASIL； CADASIL1； CASIL； IMF2； LMNS； NOTCH3； notch receptor 3； notch receptor 3； neurogenic locus notch homolog protein 3； Notch homolog 3； notch 3； Notch同源物3(NOTCH3)； 跨膜受体蛋白Notch-3；
背景信息：
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
