基因名：
NSF
产品别名：
DEE96； SEC18； SKD2； NSF； N-ethylmaleimide sensitive factor, vesicle fusing ATPase； N-ethylmaleimide sensitive factor, vesicle fusing ATPase； vesicle-fusing ATPase； N-ethylmaleimide-sensitive factor-like protein； N-ethylmaleimide-sensitive fusion protein； NEM-sensitive fusion protein； epididymis secretory sperm binding protein； vesicular-fusion protein NSF； N-乙基顺丁烯二酰亚胺敏感融合蛋白； N-乙基马来酰亚胺敏感因子(NSF)；
背景信息：
Several protein-protein interactions are essential to membrane fusion during endocytosis. Membrane fusion requires interaction among SNARE1 proteins associated with both donor and acceptor membranes (1,2). Following membrane fusion, the α-SNAP cytoplasmic adapter protein binds to the SNARE complex. N-ethylmaleimide-sensitive factor (NSF), a hexameric ATPase, then associates with the α-SNAP/SNARE complex to mediate SNARE disassembly during membrane fusion (3,4). The ATPase activity of NSF induces a conformational change in the α-SNAP/SNARE complex that leads to its dissociation from the membrane, membrane fusion and eventual recycling of the SNARE complex for subsequent membrane fusion (3,4).
