基因名:
NTRK2
产品别名:
DEE58; EIEE58; GP145-TrkB; OBHD; TRKB; trk-B; NTRK2; neurotrophic receptor tyrosine kinase 2; neurotrophic receptor tyrosine kinase 2; BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; neurotrophic tyrosine kinase receptor type 2; tropomyosin-related kinase B; tyrosine kinase receptor B; 原肌球蛋白受体激酶B(TrkB); 磷酸化酪氨酸激酶B; 磷酸化酪氨酸激酶B(Tyr817)+O16092; 酪氨酸激酶B;
背景信息:
The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.