基因名：
NTRK3
产品别名：
GP145-TrkC； TRKC； gp145(trkC)； NTRK3； neurotrophic receptor tyrosine kinase 3； neurotrophic receptor tyrosine kinase 3； NT-3 growth factor receptor； ETS related protein-neurotrophic receptor tyrosine kinase fusion protein； ETV6-NTRK3 fusion； neurotrophic tyrosine kinase, receptor, type 3； tyrosine kinase receptor C； 神经酪氨酸激酶受体3(NTRK3)； 酪氨酸激酶受体C；
背景信息：
NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
