基因名：
DDR2
产品别名：
MIG20a； NTRKR3； TKT； TYRO10； WRCN； DDR2； discoidin domain receptor tyrosine kinase 2； discoidin domain receptor tyrosine kinase 2； discoidin domain-containing receptor 2； CD167 antigen-like family member B； cell migration-inducing protein 20； discoidin domain receptor 2； discoidin domain receptor family, member 2； discoidin domain-containing receptor tyrosine kinase 2； hydroxyaryl-protein kinase； migration-inducing gene 16 protein； neurotrophic tyrosine kinase receptor related 3； receptor protein-tyrosine kinase TKT； tyrosine-protein kinase TYRO10； 盘状结构域受体家族成员2(DDR2)； 盘状结构域受体蛋白2；
背景信息：
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
