基因名：
OGG1
产品别名：
HMMH； HOGG1； MUTM； OGH1； OGG1； 8-oxoguanine DNA glycosylase； 8-oxoguanine DNA glycosylase； N-glycosylase/DNA lyase； 8-hydroxyguanine DNA glycosylase； AP lyase； DNA-apurinic or apyrimidinic site lyase； OGG1 type 1f； 8-羟基鸟嘌呤DNA糖基化酶+O16017； 8-羟基鸟嘌呤糖苷酶1(OGG1)；
背景信息：
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.
