基因名：
PA2G4
产品别名：
EBP1； HG4-1； p38-2G4； PA2G4； proliferation-associated 2G4； proliferation-associated 2G4； proliferation-associated protein 2G4； ErbB-3 binding protein 1； ErbB-3 receptor binding protein； ErbB3-binding protein Ebp1； cell cycle protein p38-2G4 homolog； erbB3-binding protein 1； proliferation-associated 2G4, 38kD； proliferation-associated 2G4, 38kDa； erbB3结合蛋白1； 增殖关联蛋白2G4(PA2G4)；
背景信息：
EBP1 is a member of the peptidase M24C family and functions as an RNA-binding protein involved in cellular proliferation and differentiation processes. It is expressed in a variety of cell lines, including a wide range of tumor cell lines, and localizes to the cytoplasm. Upon treatment with Neuregulin-1 (heregulin), EBP1 translocates to the nucleus. EBP1 is a component of pre-ribosomal ribonucleoprotein complexes, participating in ribosome assembly and regulating the later steps of rRNA processing. In addition, EBP1 interacts with ErbB-3 and may function as a modulator of the ErbB-3-mediated signal transduction pathway by regulating the effects of Neuregulin-1 (heregulin). EBP1 also associates with histone deacetylases (HDACs), functioning as a transcriptional co-repressor of cell cycle regulatory genes.
