基因名：
PRDX1
产品别名：
MSP23； NKEF-A； NKEFA； PAG； PAGA； PAGB； PRX1； PRXI； TDPX2； PRDX1； peroxiredoxin 1； peroxiredoxin 1； peroxiredoxin-1； epididymis secretory sperm binding protein； natural killer cell-enhancing factor A； natural killer-enhancing factor A； proliferation-associated gene A； proliferation-associated gene protein； thioredoxin peroxidase 2； thioredoxin-dependent peroxide reductase 2； thioredoxin-dependent peroxiredoxin 1； 过氧化还原酶1； 过氧化还原酶1(PRDX1)；
背景信息：
Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.
