基因名:
PAM
产品别名:
PAL; PHM; PAM; peptidylglycine alpha-amidating monooxygenase; peptidylglycine alpha-amidating monooxygenase; peptidyl-glycine alpha-amidating monooxygenase; pancreatic peptidylglycine alpha-amidating monooxygenase; peptidyl alpha-amidating enzyme; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidylamidoglycolate lyase; peptidylglycine 2-hydroxylase; peptidylglycine alpha-hydroxylating monooxygenase; 肽酰甘氨酸2羟化酶; 肽酰甘氨酸α酰胺化单加氧酶(PAM); 肽酰甘氨酸α酰胺化单加氧酶(PAM)真核蛋白;
背景信息:
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008]