基因名：
PRKN
产品别名：
AR-JP； LPRS2； PARK2； PDJ； PRKN； parkin RBR E3 ubiquitin protein ligase； parkin RBR E3 ubiquitin protein ligase； E3 ubiquitin-protein ligase parkin； Parkinson disease (autosomal recessive, juvenile) 2, parkin； parkinson juvenile disease protein 2； parkinson protein 2 E3 ubiquitin protein ligase； parkinson protein 2, E3 ubiquitin protein ligase (parkin)； 帕金森氏病蛋白2(PARK2)； 帕金蛋白； 磷酸化帕金森病蛋白2； 磷酸化帕金蛋白；
背景信息：
Parkinson's Disease, the second most common neurodegenerative disease after Alzheimer's Disease, is characterized by the loss of dopaminergic neurons and the presence of Lewy bodies (comprised of alpha synuclein and parkin inclusions). Autosomal Recessive Juvenile Parkinsonism (AR-JP) is a recently described form of Parkinson's Disease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome.
