基因名：
PAWR
产品别名：
PAR4； Par-4； PAWR； pro-apoptotic WT1 regulator； pro-apoptotic WT1 regulator； PRKC apoptosis WT1 regulator protein； PRKC, apoptosis, WT1, regulator； WT1-interacting protein； prostate apoptosis response protein 4； prostate apoptosis response protein PAR-4； prostate apoptosis response-4； transcriptional repressor PAR4； 前列腺细胞凋亡反应蛋白4； 蛋白酶激活受体4(PAR4)；
背景信息：
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
