基因名：
CHMP1A
产品别名：
CHMP1； PCH8； PCOLN3； PRSM1； VPS46-1； VPS46A； CHMP1A； charged multivesicular body protein 1A； charged multivesicular body protein 1A； charged multivesicular body protein 1a； charged multivesicular body protein 1/chromatin modifying protein 1； chromatin modifying protein 1A； procollagen (type III) N-endopeptidase； protease, metallo, 1, 33kD； vacuolar protein sorting-associated protein 46-1； 染色质修饰蛋白1A；
背景信息：
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein PCGF4/BMI1 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargoes of viral proteins.
