基因名：
PCYT1A
产品别名：
CCTA； CCTalpha； CT； CTA； CTPCT； PCYT1； SMDCRD； PCYT1A； phosphate cytidylyltransferase 1A, choline； phosphate cytidylyltransferase 1A, choline； choline-phosphate cytidylyltransferase A； CCT A； CCT-alpha； CT A； CTP:phosphocholine cytidylyltransferase A； CTP:phosphocholine cytidylyltransferase-alpha； choline-phosphate cytidylyltransferase alpha； phosphate cytidylyltransferase 1, choline, alpha； phosphorylcholine transferase A； phosphorylcholine transferase alpha； 磷酸乙醇胺转移酶A；
背景信息：
Increase in fetal surfactant synthesis and lung maturity is caused by the glucocorticoidal induction of enzymes required for phosphatidylcholine synthesis towards the end of gestation (1). The regulation of gestational age-dependent induction of phosphatidylcholine synthesis by glucocorticoids is still unclear (1). The rate-controlling enzyme in the phosphatidylcholine biosynthetic pathway is CTP-phosphocholine cytidylyltransferase A (CCT A) (2–4). In cultured eukaryotic cells, this enzyme is essential for survival (3). The alpha isoform is located in the nucleus and is regulated by reversible phosphorylation and membrane association (3). There is significant identity between the alpha-helical membrane-binding domains of CCT A and soybean oleosin (2). Expressed CCT A has lipid-dependent cytidylyltransferase activity (5). The gene which encodes CCT A maps to human chromosome 3q (4).
