基因名：
PDGFB
产品别名：
IBGC5； PDGF-2； PDGF2； SIS； SSV； c-sis； PDGFB； platelet derived growth factor subunit B； platelet derived growth factor subunit B； platelet-derived growth factor subunit B； PDGF subunit B； PDGF, B chain； becaplermin； epididymis secretory sperm binding protein； platelet-derived growth factor 2； platelet-derived growth factor B chain； platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)； platelet-derived growth factor, beta polypeptide (oncogene SIS)； proto-oncogene c-Sis； 血小板衍生生长因子B(PDGFB)；
背景信息：
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
