基因名：
PER1
产品别名：
PER； RIGUI； hPER； PER1； period circadian regulator 1； period circadian regulator 1； period circadian protein homolog 1； Period, drosophila, homolog of； circadian clock protein PERIOD 1； circadian pacemaker protein RIGUI； hPER1； period circadian clock 1； period homolog 1； 昼夜节律蛋白1(PER1)； 节律抑制蛋白PER1；
背景信息：
In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT 3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila PER. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL 1 transactivation complex.
