基因名：
POLD1
产品别名：
CDC2； CRCS10； MDPL； POLD； POLD1； DNA polymerase delta 1, catalytic subunit； DNA polymerase delta 1, catalytic subunit； DNA polymerase delta catalytic subunit； 3'-5' exodeoxyribonuclease； CDC2 homolog； DNA polymerase subunit delta p125； polymerase (DNA directed), delta 1, catalytic subunit 125kDa； polymerase (DNA) delta 1, catalytic subunit； DNA指导聚合酶δ1(POLd)； DNA聚合酶δ催化亚单位/DNA polδcat；
背景信息：
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). Exonucleases involved in these processes include DNA polymerases, including DNA pol ? and é. DNA pol ? consists of two subunits, p125 which interacts directly with the sliding DNA clamp protein PCNA, and p50 (3,4). DNA pol ? can be regulated by cell cycle proteins (5). DNA pol é is a multiple subunit enzyme, the catalytic subunit of which is encoded by the POL2 gene (6,7). The exact reactions catalyzed by DNA pol ? and é on leading and lagging strands have not yet been elucidated.
