基因名：
POU3F2
产品别名：
BRN2； N-Oct3； OCT7； OTF-7； OTF7； POUF3； brn-2； oct-7； POU3F2； POU class 3 homeobox 2； POU class 3 homeobox 2； POU domain, class 3, transcription factor 2； brain-2； brain-specific homeobox/POU domain protein 2； nervous system-specific octamer-binding transcription factor N-Oct-3； octamer-binding protein 7； octamer-binding transcription factor 7； 大脑蛋白2；
背景信息：
The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU domain proteins. Expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons, Brn-1 and Brn-2 appear to critically control the initiation of radial migration of cortical neurons. Brn-2 is thought to be involved in smooth muscle cell development and differentiation. Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. Brn-3a has two functional transactivating domains, one at the amino terminus and one at the carboxy terminus. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor.
