基因名：
PPBP
产品别名：
B-TG1； Beta-TG； CTAP-III； CTAP3； CTAPIII； CXCL7； LA-PF4； LDGF； MDGF； NAP-2； PBP； SCYB7； TC1； TC2； TGB； TGB1； THBGB； THBGB1； PPBP； pro-platelet basic protein； pro-platelet basic protein； platelet basic protein； C-X-C motif chemokine 7； CXC chemokine ligand 7； beta-thromboglobulin； chemokine (C-X-C motif) ligand 7； connective tissue-activating peptide III； leukocyte-derived growth factor； low-affinity platelet factor IV； macrophage-derived growth factor； neutrophil-activating peptide 2； small inducible cytokine B7； small inducible cytokine subfamily B, member 7； thrombocidin 1； thrombocidin 2； thromboglobulin, beta-1； 中性粒细胞活性蛋白2/血小板碱性蛋白； 趋化因子(C-X-C基序)配体7( CXCL7)；
背景信息：
Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, βTG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
