基因名：
PRKAB1
产品别名：
AMPK； HAMPKb； PRKAB1； protein kinase AMP-activated non-catalytic subunit beta 1； protein kinase AMP-activated non-catalytic subunit beta 1； 5'-AMP-activated protein kinase subunit beta-1； 5'-AMP-activated protein kinase beta-1 subunit； AMP-activated protein kinase beta subunit； AMPK beta -1 chain； AMPK beta 1； AMPK subunit beta-1； AMPKb； protein kinase, AMP-activated, beta 1 non-catalytic subunit； protein kinase, AMP-activated, noncatalytic, beta-1； AMP激活蛋白激酶β1(PRKAb1)； 磷酸化腺苷单磷酸活化蛋白激酶β1； 腺苷单磷酸活化蛋白激酶β1；
背景信息：
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
