基因名：
PRKACB
产品别名：
CAFD2； PKA C-beta； PKACB； PRKACB； protein kinase cAMP-activated catalytic subunit beta； protein kinase cAMP-activated catalytic subunit beta； cAMP-dependent protein kinase catalytic subunit beta； protein kinase A catalytic subunit beta； protein kinase, cAMP-dependent, beta catalytic subunit； protein kinase, cAMP-dependent, catalytic, beta； 磷酸化蛋白激酶Aβ； 磷酸化蛋白激酶C亚性； 蛋白激酶受体相关1β；
背景信息：
PRKACA and PRKACB are members of the Ser/Thr protein kinase family and are a catalytic subunit of cAMP-dependent protein kinase. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011]
