基因名：
PKN1
产品别名：
DBK； PAK-1； PAK1； PKN； PKN-ALPHA； PRK1； PRKCL1； PKN1； protein kinase N1； protein kinase N1； serine/threonine-protein kinase N1； protease-activated kinase 1； protein kinase C-like 1； protein kinase C-like PKN； protein kinase C-related kinase 1； protein kinase PKN-alpha； serine-threonine kinase N； serine/threonine protein kinase N； 蛋白激酶C相关激酶1； 蛋白激酶N1(PKN1)；
背景信息：
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
