基因名：
PRKCSH
产品别名：
AGE-R2； G19P1； GIIB； PCLD； PCLD1； PKCSH； PLD1； VASAP-60； PRKCSH； protein kinase C substrate 80K-H； protein kinase C substrate 80K-H； glucosidase 2 subunit beta； AGE-binding receptor 2； advanced glycation end-product receptor 2； glucosidase II subunit beta； hepatocystin； protein kinase C substrate 60.1 kDa protein heavy chain； protein kinase C substrate, 80 Kda protein； 葡萄糖苷酶2β/Glucosidase IIβ；
背景信息：
Trimming of glucoses from N-linked core glycans on newly synthesized glycoproteins occurs sequentially through the action of Glucosidases I and II in the endoplasmic reticulum (ER). Glucosidase II is an ER-localized enzyme that contains a and b subunits (Glucosidase IIa and Glucosidase IIb) which form a defined heterodimeric complex. Glucosidase IIa is the catalyitc core of the enzyme and can function independently of the b subunit. The sequence of Glucosidase IIb encodes protein rich in glutamic and aspartic acid with a putative ER retention signal (HDEL) at the C-terminus. The phosphorylated form of Glucosidase IIb is localized in the plasma membrane and is highly expressed in FGF-stimulated fibroblasts and epidermal carcinoma cells. Glucosidase IIb was first purified from a human carcinoma cell line as a potential substrate for protein kinase C. Through the HDEL signal at the C-terminus, Glucosidase IIb retains the complete complex in the ER.
