基因名：
MAPK10
产品别名：
JNK3； JNK3A； PRKM10； SAPK1b； p493F12； p54bSAPK； MAPK10； mitogen-activated protein kinase 10； mitogen-activated protein kinase 10； mitogen-activated protein kinase 10； JNK3 alpha protein kinase； MAP kinase 10； MAP kinase p49 3F12； c-Jun N-terminal kinase 3； stress activated protein kinase beta； stress-activated protein kinase 1b； stress-activated protein kinase JNK3； 丝裂原激活蛋白激酶10(MAPK10)； 氨基末端激酶3；
背景信息：
MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
