重组干扰素诱导蛋白p58ipk

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重组干扰素诱导蛋白p58ipk

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Recombinant DNAJC3
Recombinant DnaJ heat shock protein family (Hsp40) member C3 protein

基因名：

DNAJC3

产品别名：

ACPHD； ERdj6； HP58； P58； P58IPK； PRKRI； p58(IPK)； DNAJC3； DnaJ heat shock protein family (Hsp40) member C3； DnaJ heat shock protein family (Hsp40) member C3； dnaJ homolog subfamily C member 3； DnaJ (Hsp40) homolog, subfamily C, member 3； ER-resident protein ERdj6； endoplasmic reticulum DNA J domain-containing protein 6； interferon-induced, double-stranded RNA-activated protein kinase inhibitor； protein kinase inhibitor of 58 kDa； protein kinase inhibitor p58； protein-kinase, interferon-inducible double stranded RNA dependent inhibitor；干扰素诱导蛋白p58ipk；

背景信息：

DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress. It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70.DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1. DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable).