基因名：
THAP12
产品别名：
DAP4； P52rIPK； PRKRIR； THAP0； THAP12； THAP domain containing 12； THAP domain containing 12； 52 kDa repressor of the inhibitor of the protein kinase； 58 kDa interferon-induced protein kinase-interacting protein； P58IPK-regulatory protein； THAP domain-containing protein 0； THAP domain-containing protein 12； death-associated protein 4； inhibitor of protein kinase PKR； p58IPK-interacting protein； protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)； testicular tissue protein Li 133； 原钙粘蛋白β11； 蛋白激酶PKR抑制蛋白PRKRIR；
背景信息：
PCDHB11 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. PCDHB11 clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
