基因名:
PROC
产品别名:
APC; PC; PROC1; THPH3; THPH4; PROC; protein C, inactivator of coagulation factors Va and VIIIa; protein C, inactivator of coagulation factors Va and VIIIa; vitamin K-dependent protein C; Protein C-Nagoya; activated protein C; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; coagulation factor XIV; prepro-protein C; type I protein C; 维生素K依赖的蛋白C轻链; 维生素K依赖的蛋白C重链; 蛋白C(PROC); 蛋白C激活肽;
背景信息:
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].