基因名：
PRTN3
产品别名：
ACPA； AGP7； C-ANCA； CANCA； MBN； MBT； NP-4； NP4； P29； PR-3； PR3； PRTN3； proteinase 3； proteinase 3； myeloblastin； C-ANCA antigen； Wegener granulomatosis autoantigen； azurophil granule protein 7； leukocyte proteinase 3； neutrophil proteinase 4； serine proteinase, neutrophil； wegener autoantigen； 白细胞蛋白酶3； 蛋白酶3(PR3)；
背景信息：
Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
