基因名：
PSMD10
产品别名：
dJ889N15.2； p28； p28(GANK)； PSMD10； proteasome 26S subunit, non-ATPase 10； proteasome 26S subunit, non-ATPase 10； 26S proteasome non-ATPase regulatory subunit 10； 26S proteasome regulatory subunit p28； ankyrin repeat protein； gankyrin； hepatocellular carcinoma-associated protein p28-II； proteasome (prosome, macropain) 26S subunit, non-ATPase, 10； 非ATP酶蛋白酶体26S亚基10(PSMD10)；
背景信息：
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
