基因名：
PSMD12
产品别名：
Rpn5； STISS； p55； PSMD12； proteasome 26S subunit, non-ATPase 12； proteasome 26S subunit, non-ATPase 12； 26S proteasome non-ATPase regulatory subunit 12； 26S proteasome regulatory subunit RPN5； 26S proteasome regulatory subunit p55； proteasome (prosome, macropain) 26S subunit, non-ATPase, 12； 26S蛋白酶调节亚型p55；
背景信息：
In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex and two 19S regulatory particles which recognize and unfold ubiquitinated proteins. PSMD12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12), also known as p55 or Rpn5, is a 456 amino acid protein belonging to the proteasome subunit p55 family. PSMD12 acts as a regulatory subunit of the 26S proteasome and is a component of the PA700 complex. PSMD12 contains one PCI domain.
