基因名：
PSME2
产品别名：
PA28B； PA28beta； REGbeta； PSME2； proteasome activator subunit 2； proteasome activator subunit 2； proteasome activator complex subunit 2； 11S regulator complex beta subunit； 11S regulator complex subunit beta； MCP activator, 31-kD subunit； REG-beta； activator of multicatalytic protease subunit 2； cell migration-inducing protein 22； proteasome (prosome, macropain) activator subunit 2 (PA28 beta)； proteasome activator 28 subunit beta； proteasome activator 28-beta； proteasome activator hPA28 subunit beta； 蛋白酶激活亚基2(PSME2)； 蛋白酶激活复合物亚基2；
背景信息：
PA28 (also called the 11S regulatory complex) is another activator of the 20S proteasome, which assembles on either one or both ends of the 20S proteasome in an ATP-independent manner. PA28 can greatly enhance the peptidase activities of the 20S proteasome, but not for degradation of ubiquitinated proteins. The PA28 activator is a complex of two alternating homologous subunits, PA28α and PA28β, which assembles as a hexameric ring with an α3β3 stoichiometry. PA28α and PA28β are induced by interferon. Functionally, PA28 enhances the generation of class I peptides for antigen presentation. The third subunit, PA28γ, was recently identified in the nucleus. Recombinant PA28α and PA28β form a heptomeric ring; whereas PA28γ forms a hexameric ring. All of them can stimulate the peptidase activities of the 20S proteasome.
