基因名：
PTGDS
产品别名：
L-PGDS； LPGDS； PDS； PGD2； PGDS； PGDS2； PTGDS； prostaglandin D2 synthase； prostaglandin D2 synthase； prostaglandin-H2 D-isomerase； PGD2 synthase； beta-trace protein； cerebrin-28； glutathione-independent PGD synthase； glutathione-independent PGD synthetase； lipocalin-type prostaglandin D synthase； prostaglandin D synthase； prostaglandin D2 synthase 21kDa (brain)； testis tissue sperm-binding protein Li 63n； 前列腺素D2合成酶(PTGDS)； 前列腺素D合酶(PTGDS)；
背景信息：
Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.
