基因名：
PTN
产品别名：
HARP； HB-GAM； HBBM； HBGF-8； HBGF8； HBNF； HBNF-1； NEGF1； OSF-1； PTN； pleiotrophin； pleiotrophin； pleiotrophin； heparin affin regulatory protein； heparin-binding brain mitogen； heparin-binding growth factor 8； heparin-binding growth-associated molecule； heparin-binding neurite outgrowth promoting factor； heparin-binding neurite outgrowth-promoting factor 1； osteoblast-specific factor 1； pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)； 多效生长因子； 多效生长因子(PTN)； 多效生长因子(PTN)真核蛋白；
背景信息：
Pleiotrophin (PTN) is an secreted, strongly heparinbinding,developmentally regulated cytokine. PTN and midkine share50% amino acid (aa) sequence identity, share some functions, and constitute a family. PTN is a highly conserved protein? human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity orgreater. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates its phosphatase activity, which allows increased tyrosine phosphorylation of its substrates. Increased expression of PTN is correlated withneuronal development or stresses such as brain ischemia and Parkinson’s disease.
