基因名：
PTPN11
产品别名：
BPTP3； CFC； JMML； METCDS； NS1； PTP-1D； PTP2C； SH-PTP2； SH-PTP3； SHP2； PTPN11； protein tyrosine phosphatase non-receptor type 11； protein tyrosine phosphatase non-receptor type 11； tyrosine-protein phosphatase non-receptor type 11； SH2 domain-containing protein tyrosine phosphatase 2； protein-tyrosine phosphatase 1D； protein-tyrosine phosphatase 2C； 磷酸化蛋白酪氨酸磷酸酶2； 蛋白酪氨酸磷酸酶2； 非受体型蛋白酪氨酸磷酸酶11(PTPN11)；
背景信息：
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
