基因名：
PTPN12
产品别名：
PTP-PEST； PTPG1； PTPN12； protein tyrosine phosphatase non-receptor type 12； protein tyrosine phosphatase non-receptor type 12； tyrosine-protein phosphatase non-receptor type 12； protein-tyrosine phosphatase G1； 酪氨酸蛋白磷酸酶非受体型12； 非受体型蛋白酪氨酸磷酸酶12(PTPN12)；
背景信息：
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
