基因名：
PTPN13
产品别名：
FAP-1； PNP1； PTP-BAS； PTP-BL； PTP1E； PTPL1； PTPLE； hPTP1E； PTPN13； protein tyrosine phosphatase non-receptor type 13； protein tyrosine phosphatase non-receptor type 13； tyrosine-protein phosphatase non-receptor type 13； fas-associated protein-tyrosine phosphatase 1； hPTPE1； protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)； protein-tyrosine phosphatase 1E； protein-tyrosine phosphatase PTPL1； Fas相关磷酸酶1； 非受体型蛋白酪氨酸磷酸酶13(PTPN13)；
背景信息：
PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa-B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.
