基因名：
PTPRJ
产品别名：
CD148； DEP1； HPTP eta； HPTPeta； R-PTP-ETA； R-PTP-J； SCC1； PTPRJ； protein tyrosine phosphatase receptor type J； protein tyrosine phosphatase receptor type J； receptor-type tyrosine-protein phosphatase eta； CD148 antigen； density-enhanced phosphatase 1； human density enhanced phosphatase-1； protein tyrosine phosphatase, receptor type, J polypeptide； protein-tyrosine phosphatase eta； susceptibility to colon cancer 1, mouse, homolog of； 密度增强磷酸酶1(DEP1)； 蛋白酪氨酸磷酸酶CD148；
背景信息：
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
