基因名：
RAD21
产品别名：
CDLS4； HR21； HRAD21； MCD1； MGS； NXP1； SCC1； hHR21； RAD21； RAD21 cohesin complex component； RAD21 cohesin complex component； double-strand-break repair protein rad21 homolog； NXP-1； RAD21 homolog； SCC1 homolog； kleisin； nuclear matrix protein 1； protein involved in DNA double-strand break repair； sister chromatid cohesion 1； 核基质蛋白21；
背景信息：
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
