基因名：
RAF1
产品别名：
CMD1NN； CRAF； NS5； Raf-1； c-Raf； RAF1； Raf-1 proto-oncogene, serine/threonine kinase； Raf-1 proto-oncogene, serine/threonine kinase； RAF proto-oncogene serine/threonine-protein kinase； C-Raf proto-oncogene, serine/threonine kinase； Oncogene RAF1； proto-oncogene c-RAF； raf proto-oncogene serine/threonine protein kinase； v-raf-1 murine leukemia viral oncogene homolog 1； v-raf-1 murine leukemia viral oncogene-like protein 1； C-Raf原癌基因丝苏氨酸蛋白激酶(Raf-1)； 癌基因c-Raf； 磷酸化原癌基因c-Raf；
背景信息：
cRaf/Raf1 (RAF proto-oncogene serine/threonine-protein kinase) involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3. The Raf family is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen activated protein kinase (MAPK) pathway. cRaf kinase is a small GTPase like kinase of 73 kDa, and is a signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Raf1 is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is part of the Ras dependent signaling pathway from receptors to the nucleus.
