基因名:
RBBP7
产品别名:
RbAp46; RBBP7; RB binding protein 7, chromatin remodeling factor; RB binding protein 7, chromatin remodeling factor; histone-binding protein RBBP7; G1/S transition control protein-binding protein RbAp46; RBBP-7; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46; retinoblastoma-binding protein 7; retinoblastoma-binding protein RbAp46; retinoblastoma-binding protein p46; 组蛋白结合蛋白RBBP7;
背景信息:
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]