基因名：
RBBP8
产品别名：
COM1； CTIP； JWDS； RIM； SAE2； SCKL2； RBBP8； RB binding protein 8, endonuclease； RB binding protein 8, endonuclease； DNA endonuclease RBBP8； CTBP-interacting protein； RBBP-8； retinoblastoma binding protein 8； sporulation in the absence of SPO11 protein 2 homolog； 视网膜母细胞瘤结合蛋白8；
背景信息：
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
