基因名：
UPF1
产品别名：
HUPF1； NORF1； RENT1； UTF； pNORF1； smg-2； UPF1； UPF1 RNA helicase and ATPase； UPF1 RNA helicase and ATPase； regulator of nonsense transcripts 1； ATP-dependent helicase RENT1； UPF1 regulator of nonsense transcripts homolog； delta helicase； nonsense mRNA reducing factor 1； smg-2 homolog, nonsense mediated mRNA decay factor； up-frameshift mutation 1 homolog； up-frameshift suppressor 1 homolog； yeast Upf1p homolog； ATP依赖解旋酶RENT1；
背景信息：
In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (1–3). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.
